Peptide Bond

By Peptide InformationApril 21, 2025

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What Is a Peptide Bond

A peptide bond is the covalent amide linkage that connects amino acid residues within peptides and proteins. In a conventional α-peptide, it is formed between the carbonyl carbon derived from the α-carboxyl group of one amino acid and the nitrogen derived from the α-amino group of the next residue.

In structural terms, the peptide linkage is represented as:

–C(=O)–NH–

Repeated peptide bonds create the backbone of a peptide chain, extending from the N-terminus to the C-terminus. The amino acid side chains project from this backbone and contribute many of the chemical differences between individual peptides and proteins.

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